Introduction Implant-related metal sensitivity has been reported mainly in case studies and metal sensitivity (MS) develops in 20-25% of patients who have undergone total knee arthroplasty (TKA) using cobalt-chrome (Co-Cr) alloy femoral components [1,2]. Metal ions can activate the immune system by inducing a delayed type IV hypersensitivity reaction, in which
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KITAGAWA et al. (2013) studied this question.
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