Synthesis of Substituted Uracil Derivatives from the Acetates of the Baylis-Hillman Adducts

a new synthetic method of 5-substituted uracil derivatives are still of particular interest interms of new drug development. Recently, Knochel and co-workers reported the synthesis of 5-benzyl substituted uracilderivatives from zincated thymine derivatives and aryliodide in the presence of palladium reagent.