Key result
Increased expression of both Her2 and ER81 was associated with hTERT transcriptional activation in 86% of breast carcinoma specimens.
Why the study?
Does Her2 overexpression increase hTERT transcriptional activation via ER81 in breast carcinomas?
Observational (n=43)
Does Her2 overexpression increase hTERT transcriptional activation via ER81 in breast carcinomas?
Her2 overexpression may increase hTERT transcriptional activation in breast carcinomas, potentially mediated by ER81.
Supports Her2-ER81-hTERT association in breast cancer; hypothesis-generating and leaves open clinical relevance.
Her2 and ER81 (a member of ETS family) have been suggested to cause a synergistic increase in the transcriptional activation of hTERT. Our study aimed to offer further confirmation in clinical material. We determined the mRNA levels of Her2, ER81, and hTERT, by QRT-PCR, in 43 breast carcinomas. In the specimens showing hTERT transcriptional activation, Her2 and ER81 were increased in statistically significant tumor subgroups (61% and 79% correspondingly). The 86% of specimens with both Her2 and ER81 increased expression showed hTERT transcriptional activation. Synchronous transcriptional activation of hTERT, Her2, and ER81 elevated expression was noted in 42% of the samples. In conclusion, we agree with a previous study that Her2 overexpression may increase the hTERT transcriptional activation. Our data indicate that the mechanism may involve Her2-ER81 interaction(s) and that the activation of hTERT could be mainly mediated by transcriptional activation of ER81.
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Vageli et al. (2009) conducted an observational in Breast carcinomas (n=43). Her2 and ER81 expression was evaluated on hTERT transcriptional activation. Increased expression of both Her2 and ER81 was associated with hTERT transcriptional activation in 86% of breast carcinoma specimens.
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