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January 1, 2004Biological and Pharmaceutical BulletinOpen Access

A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm

Koichi Shudo Hiroyuki Kagechika Noriyuki Yamazaki Masaharu Igarashi Chiaki Tateda

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Abstract

Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.

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Shudo et al. (2004) studied this question.

synapsesocial.com/papers/6ab89111fe001c60b4b148c7 https://doi.org/10.1248/bpb.27.1887

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