Key result
The long non-coding RNA Gm10768 activates hepatic gluconeogenesis in mice by sequestering microRNA-214 and relieving its suppression on activating transcription factor 4.
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Caution against extrapolating mouse lncRNA effects to humans; leaves open therapeutic targeting of Gm10768 in metabolic disease.
mice. Mechanistically, Gm10768 sequestrated microRNA-214 (miR-214) to relieve its suppression on activating transcription factor 4 (ATF4), a positive regulator of hepatic gluconeogenesis. Taken together, we identified Gm10768 as a new lncRNA activating hepatic gluconeogenesis through antagonizing miR-214 in mice.
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Cui et al. (2018) studied this question. The long non-coding RNA Gm10768 activates hepatic gluconeogenesis in mice by sequestering microRNA-214 and relieving its suppression on activating transcription factor 4.
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