The Role of Gamma Amino Butyric Acid in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

Figures

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  Figure 1. Serum levels of creatinine, blood urea nitrogen, and blood urea nitrogen/creatinine ratio and kidney weight per 100 g of body weight body weight change (delta body weight), uterus weight per 100 g of body weight, in 5 experimental groups in male and female streptozotocin-induced diabetic rats. Gamma amino butyric acid: Group received gamma amino butyric acid alone. Cisplatin: Group received cisplatin alone. Gamma amino (Prophylaxis-treatment) + cisplatin: Group received gamma amino butyric acid as prophylaxis and then treated with both gamma amino butyric acid and cisplatin. Gamma amino (therapy) + cisplatin: Group treated with gamma amino butyric acid and cisplatin simultaneously. Gamma amino (prophylaxis) + cisplatin: Group received gamma amino butyric acid as prophylaxis and then treated with cisplatin alone. *, # and † means significant difference from gamma amino butyric acid, cisplatin and gamma amino (prophylaxis-treatment) + cisplatin groups, respectively, P < 0.05

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  Figure 2. The images (magnification 100) of kidney tissue in 5 experimental groups in male and female streptozotocin-induced diabetic rats. Gamma amino butyric acid: Group received gamma amino butyric acid alone. Cisplatin: Group received cisplatin alone. Gamma amino (prophylaxis-treatment) + cisplatin: Group received gamma amino butyric acid as prophylaxis and then treated with both gamma amino butyric acid and cisplatin. Gamma amino (therapy) + cisplatin: Group treated with gamma amino butyric acid and cisplatin simultaneously. Gamma amino (prophylaxis) + cisplatin: Group received gamma amino butyric acid as prophylaxis and then treated with cisplatin alone