Key result
Severe aortic stenosis is linked to a ~3-fold higher mortality in early-stage cancer.
Why the study?
The characteristics and prognosis of cancer patients with aortic stenosis under conservative cardiac therapy are not well known.
Cohort (n=562)
No
Answers are grounded in this paper and cite their sources.
Early-stage cancer patients with severe AS had excess HF mortality under conservative care; supports AVR consideration but leaves open prospective validation.
Aortic stenosis (AS) is a life-threatening comorbidity of cancer patients. Aortic valve replacement (AVR) should be considered for some cancer patients, but neither the characteristics nor prognosis under conservative therapy is well known.
No takes yet. Share an insight, caveat, or question.
Okura et al. (2018) conducted a cohort in Cancer with Aortic Stenosis (n=562). Aortic stenosis vs. Matched cancer patients without aortic stenosis was evaluated on Mortality in stage I-II cancer patients with severe aortic stenosis (AVA < 0.75 cm2) (HR 3.04, 95% CI 1.18-7.84, p=0.021). Severe aortic stenosis (aortic valve area < 0.75 cm2) was associated with a significantly higher risk of mortality in patients with stage I or II cancer compared to matched controls without aortic stenosis (HR 3.04).
Synapse has enriched 10 related papers. Consider them for comparative context: