Key result
Tranexamic acid and aminocaproic acid fail to reverse dabigatran-induced coagulopathy in preclinical testing.
Why the study?
No clearly established reversal agent exists for rapid reversal of dabigatran-induced coagulopathy.
Do tranexamic acid or aminocaproic acid reverse dabigatran-induced coagulopathy in a rat model?
Population
Rats with dabigatran-induced coagulopathy
Comparison
Tranexamic acid or aminocaproic acid vs saline
Design
Randomized controlled preclinical trial
Authors
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Preclinical rodent data advise against relying on these agents for dabigatran reversal; leaves open human efficacy and need for specific antidotes.
RCT
Randomly assigned to 6 groups
Do tranexamic acid or aminocaproic acid reverse dabigatran-induced coagulopathy in a rat model?
Tranexamic acid and aminocaproic acid are ineffective at reversing dabigatran-induced coagulopathy in a preclinical rodent model.
Levine et al. (2015) conducted an RCT in Dabigatran-induced coagulopathy. Tranexamic acid and aminocaproic acid vs. Saline was evaluated on Coagulopathy measured by activated clotting test. Neither tranexamic acid nor aminocaproic acid successfully reversed dabigatran-induced coagulopathy in a rodent model.
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