A novel approach to the synthesis of L-[S-methyl-11C]methionine ([11C]MET) is described which involves a commercial C18 Sep-Pak Plus as a solid-phase support material for the [11C]methylation step. The present method, which uses [11C]CH3I produced by the classical LiA1H4/HI route, supplies [11C]MET ready for injection within 11 min from the end of bombardment (EOB) with a radiochemical yield, decay corrected at EOB, of 78% and a radiochemical purity at the end of synthesis (EOS) higher than 99%. The required setup is extremely simple and easy to automate and can be reset for a further synthesis within a few minutes. Moreover, due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation.
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Pascali et al. (1999) studied this question.