Key result
A third immunization with Wuhan-based SARS-CoV-2 Spike vaccines significantly increased neutralizing antibody titers against variants of concern, including Beta, in mice, rabbits, and macaques.
Why the study?
Does a third vaccination with experimental Wuhan-based Spike vaccines improve neutralizing antibody titers against SARS-CoV-2 variants-of-concern in animal models?
Population
Mice, rabbits, and non-human primates
Comparison
Third vaccination with experimental Wuhan-based… vs Two vaccinations with experimental Wuhan-based…
Design
Preclinical
Authors
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Animal data justify human booster trials against variants; leaves open clinical protection and durability.
Does a third vaccination with experimental Wuhan-based Spike vaccines improve neutralizing antibody titers against SARS-CoV-2 variants-of-concern in animal models?
A third dose of Wuhan-based SARS-CoV-2 Spike vaccine restores neutralizing antibody titers against variants of concern to levels comparable to two doses against the original strain in animal models.
Brinkkemper et al. (2021) studied SARS-CoV-2 (n=26). Third vaccination with Wuhan-based SARS-CoV-2 Spike vaccines vs. Two vaccinations was evaluated on Neutralizing antibody titers (ID50) against SARS-CoV-2 variants of concern. A third immunization with Wuhan-based SARS-CoV-2 Spike vaccines significantly increased neutralizing antibody titers against variants of concern, including Beta, in mice, rabbits, and macaques.
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