Key result
Lqh-3 was about 100-times more potent in removing inactivation in hNaV1.7 channels compared with rNaV1.2, whereas Lqh-2 was about 20-times more active in the opposite direction.
The scorpion toxins Lqh-2 and Lqh-3 exhibit differential sensitivity to central (NaV1.2) and peripheral (NaV1.7) nervous system sodium channels, with the S3-4 linkers of domain 4 playing a major role for Lqh-3 binding.
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May inform NaV subtype-selective modulator design; leaves open clinical translation from this animal data.
Chen et al. (2002) studied this question. Scorpion alpha-toxins Lqh-2 and Lqh-3 was evaluated on Removal of fast inactivation in rNaV1.2 and hNaV1.7 channels. Lqh-3 was about 100-times more potent in removing inactivation in hNaV1.7 channels compared with rNaV1.2, whereas Lqh-2 was about 20-times more active in the opposite direction.
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