A New Anti-influenza Virus Antibiotic, 10-Norparvulenone from Microsphaeropsis sp. FO-5050.

Influenza virus infection is widespread and sometimes critical for patients with respiratory diseases, immunosuppressive syndromes such as AIDS, aged persons with cardiopulmonary diseases and so on1}.Although several anti-influenza virus agents such as amantadine, rimantadine and zanamivir have been used, they are not always effective.The side-effects and rapid development of viral resistance cause limited medical application2'^.For these reasons, new effective anti-influenza viral drugs are required.Recently, we screened anti-influenza virus compounds from culture broths of actinomycetes and fungi.The screening was