High positive predictive value of Xpert in a low rifampicin resistance prevalence setting To the Editor: Although drug susceptible tuberculosis (TB) is a curable disease, spread of rifampicin-resistant TB, including multidrug-resistant (MDR)-and extensively drug-resistant (XDR)-TB, is a threat to disease control worldwide [1], in particular in Eastern Europe [2].XpertMTB/RIF (Xpert; Cepheid Inc., Sunnyvale, CA, USA) is an accurate [3] and affordable [4] automated PCR-based assay that detects DNA of Mycobacterium tuberculosis and resistance to rifampicin in ,2 h [5].
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Trajman et al. (2014) studied this question.
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