Key result
Depressive episodes linked to significantly lower total cholesterol and LDL levels versus healthy controls.
Why the study?
Lower levels of circulating lipid fractions and cholesterol are risk factors for impulsivity and depressive disorder, but their association with depressive episodes in Indian patients needed investigation.
Are serum lipid profiles altered in Indian patients with depressive episode compared to healthy controls?
Case-Control (n=60)
No
Are serum lipid profiles altered in Indian patients with depressive episode compared to healthy controls?
Lower levels of serum total cholesterol and LDL are associated with depressive disorder in Indian patients.
Lower cholesterol may mark depressive episodes in Indian patients; hypothesis-generating and should not yet change practice.
BACKGROUND: Lower levels of circulating lipid fractions and cholesterol are risk factors for impulsivity and depressive disorder. A lower level of serum cholesterol is also associated with patients presenting with history of self-harm. MATERIALS AND METHODS: A total of 30 depressive patients and 30 healthy matched control subjects were recruited from the department of Psychiatry of a tertiary care hospital. We measured serum total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein cholesterol and triglyceride levels of both patient and control group. RESULTS: The serum TC and LDL-cholesterol levels were found to be significantly lower in study group than that of control group. CONCLUSION: Lower levels of serum cholesterol are associated with depressive disorder.
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Patra et al. (2014) conducted a case-control in Depressive Episode (n=60). Depressive episode vs. Healthy matched controls was evaluated on Serum lipid profiles (total cholesterol, LDL, HDL, and triglycerides). Patients with depressive episode had significantly lower levels of serum total cholesterol and LDL-cholesterol compared to healthy matched controls.
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