Oxidative stress in epilepsy

This article contains an analysis of clinical and experimental studies in which oxidative stress is considered as a possible mechanism in the pathogenesis of epilepsy. Oxidative stress occurs as a result of brain damage after epileptic seizures and may later cause epileptogenesis. Patients with epilepsy showed a high level of lipid peroxidation markers, while the activity of antioxidant defense system was low. The level of oxidative stress was shown to be significantly higher in epileptics with associated mental disorders and in patients with refractory epilepsy. Further study of oxidative stress in epilepsy may play the key role in the treatment of this disease.