Key result
Gastric bypass surgery cuts BMI by ~33% at 1 year in women with T1D.
Why the study?
Few studies have evaluated the long-term effects of gastric bypass surgery in patients with type 1 diabetes despite increasing obesity prevalence in this population.
Does gastric bypass surgery improve anthropometric and cardiometabolic outcomes in severely obese women with type 1 diabetes?
Cohort (n=10)
Does gastric bypass surgery improve anthropometric and cardiometabolic outcomes in severely obese women with type 1 diabetes?
Gastric bypass surgery significantly reduces BMI at 1 year in severely obese women with type 1 diabetes.
Should not yet change practice; hypothesis-generating for bariatric surgery in obese T1D, warranting controlled trials.
While the benefits of gastric bypass (GB) surgery in type 2 diabetes are well established, few studies have evaluated the long-term effects of GB in patients with type 1 diabetes (1,2), and these studies demonstrate conflicting effects on glycemic control. This is clinically important given the increasing prevalence of obesity in patients with type 1 diabetes (3). We studied 10 severely obese women with confirmed type 1 diabetes, as previously described (4), and evaluated outcomes prior to GB and at 1 and 5 years following surgery. Mean age at GB was 39.6 ± 8.4 years, mean duration of type 1 diabetes 24.6 ± 10.1 years, and mean age at diagnosis 16.0 ± 8.3 years. Six subjects used continuous subcutaneous insulin infusion. BMI decreased by 33% from baseline at 1 year postoperatively (from 43.5 ± 7.5 to 29.3 ± 5.4 kg/m2, P < 0.0001) but …
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Middelbeek et al. (2015) conducted a cohort in Severely obese women with type 1 diabetes (n=10). Gastric bypass surgery vs. Baseline (prior to surgery) was evaluated on BMI at 1 year postoperatively (p=<0.0001). Gastric bypass surgery in severely obese women with type 1 diabetes significantly reduced BMI from 43.5 to 29.3 kg/m2 at 1 year postoperatively (P<0.0001).
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