Key result
Slow heart rate recovery in young adulthood shows no association with midlife coronary artery calcium.
Why the study?
The association between slower heart rate recovery after graded exercise testing in young adults and the presence of coronary artery calcium in middle age was unclear.
Is slower heart rate recovery after exercise in young adulthood associated with the presence of coronary artery calcium 15 years later?
Cohort (n=2,648)
Yes
Is slower heart rate recovery after exercise in young adulthood associated with the presence of coronary artery calcium 15 years later?
Odds Ratio: 0.99 (95% CI 0.87–1.13)
p-value: p=0.91
Slow heart rate recovery after exercise in young adulthood is not predictive of coronary artery calcium development by middle age.
Heart rate recovery in young adults should not inform CAC risk stratification; leaves open its value for other cardiovascular outcomes in prospective studies.
We tested whether slower heart rate recovery (HRR) following graded exercise treadmill testing (GXT) was associated with the presence of coronary artery calcium (CAC). Participants (n = 2,648) ages 18-30 years at baseline examination underwent GXT, followed by CAC screening 15 years later. Slow HRR was not associated with higher odds of testing positive (yes/no) for CAC at year 15 (OR = 0.99, p = 0.91 per standard deviation change in HRR). Slow HRR in young adulthood is not associated with the presence of CAC at middle age.
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Kizilbash et al. (2007) conducted a cohort in Healthy young adults (n=2,648). Slow heart rate recovery (HRR) vs. Fast heart rate recovery (or per standard deviation change) was evaluated on Presence of coronary artery calcium (CAC score > 0) at year 15 (OR 0.99, 95% CI 0.87-1.13, p=0.91). Slow heart rate recovery following exercise in young adulthood is not associated with the presence of coronary artery calcium 15 years later at middle age (OR 0.99, p=0.91 per standard deviation change).
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