Increased internal carotid artery peak systolic velocity is associated with presence of significant atherosclerotic plaque instability independent of degree of ICA stenosis

The aim of our work was to study the relationship between Doppler ultrasound velocity measurements and the presence of histologic features of plaque instability in carotid atherosclerosis, in particular, intraplaque hemorrhage (IPH). Consecutive patients undergoing carotid endarterectomy in a one-year period were included. All patients were examined by duplex ultrasonography and carotid angiography. Endarterectomy specimens were examined histologically for features of plaque instability. The quantity of IPH was measured by digital image analysis. The associations between Peak Systolic Velocity (PSV), end-diastolic velocity (EDV), degree of ICA stenosis, shape and length of the lesion and the features of plaque instability and quantity of IPH were assessed. Seventy-four patients (20 asymptomatic, 54 symptomatic) were included. PSV was independently associated with the presence of significant IPH [ p < 0.001, OR = 1.04 (95% CI = 1.01–1.06)], as was the degree of angiographic ICA stenosis [ p < 0.05, OR = 0.98 (95% CI = 0.92–1.6)]. Neither EDV nor the shape of the lesion was associated with IPH ( p = 0.26 and p = 0.38, respectively). A close correlation was observed between PSV and the quantity of IPH ( r 2 = 0.68, p < 0.0001). A significant association was observed between PSV and the presence of plaque ulceration ( p < 0.05); however, this was not found to be independent of the quantity of IPH and the degree of ICA stenosis [ p = 0.17, OR = 1.28 (95% CI = 0.6–2.44)]. PSV at the site of ICA stenosis appears to be associated with the quantity of intraplaque hemorrhage, independent of the angiographic degree of ICA stenosis. We propose that the role of Doppler velocity measurements extends beyond measurement of the degree of ICA stenosis. Increased ICA peak systolic velocity by itself may be an indicator of atherosclerotic plaque instability.