Key result
A review of regional cerebral blood flow studies suggests schizophrenia patients have a deficient microvascular regulatory system, failing to raise rCBF in frontal and temporal lobes during tasks.
The paper proposes that deficient regional cerebral blood flow regulation in schizophrenia may be linked to local circuit neuron dysfunction and nitric oxide signaling.
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Hypothesis-generating for microvascular dysregulation in schizophrenia; leaves open cardiovascular parallels and need for prospective validation.
S. A. Bachneff (1996) conducted a review in Schizophrenia. A review of regional cerebral blood flow studies suggests schizophrenia patients have a deficient microvascular regulatory system, failing to raise rCBF in frontal and temporal lobes during tasks.
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