Key result
Cardiac arrhythmias affect ~50% of chronic Chagas heart disease patients, signaling an unfavorable prognosis.
Why the study?
Chronic Chagas' disease shows several progression modes with variable clinical manifestations and prognosis factors that require characterization.
In chronic Chagas' heart disease, the development of serious ventricular arrhythmias, conduction disturbances, and heart failure are key indicators of an unfavorable prognosis and risk of sudden death.
Chagas arrhythmias precede HF in ~50% with PE dominant in advanced phases; leaves open whether patterns persist or guide screening in modern cohorts.
Chronic Chagas' disease shows several progression modes. Usually, the different clinical syndromes manifest themselves together, however, isolated forms can occur. Cardiac arrhythmias, which are very frequent, are present in about 50% of patients. The cardiac damage manifests itself later, with the emergence of heart failure. Thromboembolism can occur in both pulmonary and systemic circulation. Pulmonary embolism is the most frequent, appearing in more advanced phases of heart disease. Sudden death is the fatal outcome of these patients. It predominates in males and generally occurs in a disease stage when patients have their highest productivity. The presence of serious ventricular arrhythmias, conduction disturbances in the electrocardiogram, and heart failure, provide an unfavorable prognosis.
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Mady et al. (1995) conducted a review in Chronic Chagas' heart disease. Cardiac arrhythmias are present in about 50% of patients with chronic Chagas' heart disease, with serious ventricular arrhythmias, conduction disturbances, and heart failure conferring an unfavorable prognosis.
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