Key result
Quinidine, procaine amide, and novel antiarrhythmics prevent calcium-induced fibrillation in rat models.
Why the study?
The effects of quinidine, procaine amide, and new antiarrhythmic compounds on calcium-induced arrhythmias in the rat were not fully characterized.
In a rat model, antiarrhythmic agents such as quinidine and procaine amide prevent calcium-induced fibrillation, which unmasks other calcium-mediated effects on cardiac rhythm.
Quinidine analogs prevent calcium-induced VF in rats but unmask other rhythm effects; leaves open clinical translation and mechanism studies.
The effect of quinidine, procaine amide and five new antiarrhythmic compounds on calcium-induced arrhythmias in the rat are described. When the compounds prevented fibrillation, the other actions of calcium on cardiac rhythm were revealed.
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Winbury et al. (1955) studied this question. Quinidine, procaine amide, and five new antiarrhythmic agents prevented calcium-induced fibrillation in rats, thereby unmasking other effects of calcium on cardiac rhythm.
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