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TAN-1057A−D, dipeptides isolated from bacteria Flexibacter sp. PK-74 and PK-176, are new antibiotics with potent antibacterial activity against methicillin-resistant Staphylococcus aureus . We describe, in detail, the total synthesis of TAN-1057A−D by a convergent route featuring a new method to construct the cyclic amidinourea functional group.
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Yuan et al. (1997) studied this question.
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