The Measurements Of The Cholinesterase Activity Of Brain And Plasma In Rabbits By Using Modified Michel And Ellman Assays

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This study deals with the measurement of acetylcholinesterase activities in the plasma and brain of 8 rabbits using modified Michael and Ellman methods. The highest values of acetylcholinesterase activities in plasma and brain were 0.37 and 0.25, respectively, when the modified Michel method was employed. In the case of using Ellman method, the highest values of cholinesterase activities in plasma and brain were 0.89 and 0.43, respectively. In order to determine the efficiency and legitimacy of the measured result, the coefficient of variation was calculated. For the modified Michael method, the coefficients of variation in plasma and brain were 17.78 % and 19.37%, respectively. However, in the case of using Ellman method, the coefficients of variation in plasma and brain were 21.72% and 41.21%, respectively. These results were consistent with those reported in the previous studies.