Oak trees from acorns: A small amount (<1 %) of a cosolvent can change the stability of the H-bonded complex on the right-hand side of the equation by an order of magnitude. Mixtures of chloroform and THF were found to be more polar than either of the pure solvents by using this complex as a molecular-recognition probe of solvation. A quantitative interpretation based on preferential solvation accounts for the properties of solvent mixtures.
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Cook et al. (2008) studied this question.
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