Coordination between Motor Domains in Processive Kinesins

Among cellular functions that kinesins perform, their ability to walk along the microtubules transporting specific cargoes is the most fascinating (1, 2). The complexity of this phenomenon and tremendous scientific efforts put toward dissecting the mechanisms underlying it have led to conflicting models explaining how kinesins might travel long distances without dissociating from their biological track (e.g. move “processively” (3)).