Key result
Insulin independently predicts reduced large artery compliance in healthy adults, unlike lipid and endothelial markers.
Why the study?
Arterial compliance is an index of vascular capacity and its loss may precede cardiovascular diseases, but factors influencing it in healthy Chinese people were not well defined.
Cross-Sectional (n=204)
In healthy Chinese individuals, insulin levels independently predict changes in large artery compliance, establishing normative values for this population.
Insulin was associated with large arterial compliance in healthy Chinese adults; hypothesis-generating and should not yet change practice.
We measured the arterial compliance of healthy Chinese people, to seeking factors influencing it. Arterial compliance is an index of the capacity of vessels to accommodate changes in blood pressure. It has been postulated that the loss of AC may precede cardiovascular diseases, such as hypertension, atherosclerosis, and coronary heart disease. Vascular tone is influenced by endothelial function and other factors. We estimated large (C1) and small vessel compliance (C2) by arterial pulse contour analysis and obtained family history, serum lipid, glucose, insulin, endothelin-1, and nitric oxide levels in 204(97men and 107women, age 45.54±15.34 years, range 16-75 ) healthy Chinese subjects. (1)Values for C1 and C2 for the entire population ranged from 5.5 to 37.7 and 0.9 to 15.7(mean 16.92±3.88 and 6.72±3.24). (2)C1 correlated negatively with glucose, TC, TG (all p<0.05)and C2 correlated negatively with glucose, TG(all p<0.05), C1 and C2 correlated positively with height, weight, sex(all p<0.001). (3)multivariate regression analysis showed that stoke volume, pulse pressure, body surface area, age, insulin independently predicted changes in C1. (4)multivariate regression analysis showed that age, stoke volume, mean arterial pressure, body surface area, independently predicted changes in C2. (5)endothelin-1, nitric oxide and the ratio of them were not correlated with C1 or C2. This study measured the normal range of C1 and C2 in Chinese healthy people. Insulin but not TC, TG, glucose, endothelin-1, nitric oxide independently predicted changes in large compliance in healthy people.
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Guang Ming Wu (2002) conducted a cross-sectional in Healthy (n=204). Clinical and biochemical factors (e.g., insulin, age, stroke volume) was evaluated on Large (C1) and small vessel compliance (C2). In healthy Chinese subjects, insulin independently predicted changes in large arterial compliance, whereas total cholesterol, triglycerides, glucose, endothelin-1, and nitric oxide did not.
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