Key result
A concise one-pot two-step synthesis of molnupiravir starting from uridine achieved up to 68% overall yield and >99% purity.
Describes a concise, one-pot two-step chemical synthesis of molnupiravir from uridine with high yield and purity.
May enable scalable molnupiravir access; leaves open prospective cardiovascular outcome trials.
A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.
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Pereira et al. (2022) studied this question. One-pot two-step synthesis of molnupiravir was evaluated on Overall yield and purity. A concise one-pot two-step synthesis of molnupiravir starting from uridine achieved up to 68% overall yield and >99% purity.
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