Key result
Roux-en-Y gastric bypass resulted in an average weight loss of 21.7±1.4 kg at 3 months, with significant decreases in fat mass, fat-free mass, and resting energy expenditure.
Why the study?
Does Roux-en-Y gastric bypass surgery alter resting energy expenditure, body composition, and thyroid hormones in morbidly obese patients?
Case-Control (n=42)
Does Roux-en-Y gastric bypass surgery alter resting energy expenditure, body composition, and thyroid hormones in morbidly obese patients?
Roux-en-Y gastric bypass leads to significant weight loss and decreases in fat mass, fat-free mass, and resting energy expenditure at 3 months.
Post-RYGB REE drop tracks FFM loss without excess vs controls; small Level 5 data leave open thyroid contributions to weight trajectories.
Introduction: One way to lose weight is bariatric surgery. Various studies have shown that after Roux-en-Y gastric bypass (RYGB), resting energy expenditure (REE) decreased may be a result of changes in fat-free mass (FFM) and thyroid-stimulating hormone levels. The aim of our study was to assess changes in body composition, REE, and thyroid hormones in patients undergoing RYGB. Methods: A total of 42 patients participated (21 undergoing RYGB and 21 age- and weight-matched subjects as controls) in our study. Weight, body-mass index, body composition, resting metabolic rate, physical activity, and thyroid hormones were measured at baseline in cases and 3 months after surgery in case and control groups. Results: At 3 months after surgery, patients lost an average of 21.7±1.4 kg weight, and fat mass, FFM, and REE decreased significantly. REE was higher in cases compared to controls. T 4 , T 3 , and thyroid-stimulating hormone at 3 months after RYGB decreased, but the decrease was significant only in T 4 compared to controls. FFM was higher and fat mass lower in cases compared to controls. Conclusion: We detected a meaningful difference in REE before and after surgery, but we did not detect any meaningful difference in REE between controls and cases.
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Mirahmadian et al. (2018) conducted a case-control in Morbid obesity (n=42). Roux-en-Y gastric bypass (RYGB) vs. Age- and weight-matched controls was evaluated on Changes in body composition, resting energy expenditure (REE), and thyroid hormones. Roux-en-Y gastric bypass resulted in an average weight loss of 21.7±1.4 kg at 3 months, with significant decreases in fat mass, fat-free mass, and resting energy expenditure.
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