What is the clinical evidence from this study?

Study design: Cohort. Population: Cardiovascular risk (n=951). Intervention: CD14++CD16+ monocytes (fourth quartile) vs. CD14++CD16+ monocytes (first quartile). Primary outcome: First occurrence of cardiovascular death, acute myocardial infarction, or nonhemorrhagic stroke (HR 3.019, 95% CI 1.315 to 6.928, p=0.009).

What question did this study set out to answer?

To evaluate the prospective relationship between distinct circulating monocyte subsets and cardiovascular outcomes in patients undergoing elective coronary angiography.

September 27, 2026Journal of the American College of CardiologyOpen Access

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Q: What are the key findings of this study?

High levels of CD14++CD16+ monocytes independently predicted cardiovascular events compared to the lowest quartile (HR 3.019; 95% CI 1.315-6.928; p=0.009).

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Key result

High CD14++CD16+ monocytes linked to ~3-fold higher cardiovascular risk vs. lowest quartile.

HR 3.019
95% CI 1.315 to 6.928
P=0.009
n=951

Why the study?

Do elevated CD14++CD16+ monocyte counts predict cardiovascular events in subjects referred for elective coronary angiography?

Population

951 subjects referred for elective coronary angiography

Comparison

Higher counts of intermediate CD14++CD16+… vs Lower counts of intermediate CD14++CD16+ monocytes

Design

Cohort, Flow cytometry blinded to clinical characteristics; endpoint…

Follow-up

mean 2.6 ± 1.0 years

Authors

KRKyrill S. RogacevCanberra Hospital BCBodo CremersInterventional Cardiology AZAdam M. ZawadaFresenius Medical Care (Germany)

Discussion

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Implication

Intermediate CD14++CD16+ monocytes are an independent predictor of cardiovascular events in patients undergoing elective coronary angiography, suggesting a potential role in atherogenesis and risk stratification.

Key Points

To evaluate the prospective relationship between distinct circulating monocyte subsets and cardiovascular outcomes in patients undergoing elective coronary angiography.
Prospective cohort study of 951 subjects undergoing elective coronary angiography, tracked over a mean follow-up of 2.6 ± 1.0 years.
Blinded flow cytometry quantified classical (CD14++CD16-), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++) monocyte subsets, stratifying patients into quartiles.
The primary endpoint was a composite of cardiovascular death, acute myocardial infarction, or nonhemorrhagic stroke, adjudicated blinded to cell counts.
During follow-up, 93 patients reached the primary endpoint; univariate analyses showed total (p = 0.010), classical (p = 0.024), and intermediate (p < 0.001) monocytes predicted events, while nonclassical monocytes did not (p = 0.158).
After multivariable adjustment, intermediate CD14++CD16+ monocytes remained the sole independent predictor of cardiovascular events (fourth vs. first quartile: HR: 3.019; 95% CI: 1.315 to 6.928; p = 0.009).

Study Design

Type

Cohort (n=951)

Blinding

Blinded endpoint adjudication

Structured PICO

Do elevated CD14++CD16+ monocyte counts predict cardiovascular events in subjects referred for elective coronary angiography?

Population

951 subjects referred for elective coronary angiography, followed for a mean of 2.6 years.

Exposure

Higher counts of intermediate CD14++CD16+ monocytes (fourth quartile)

Comparator

Lower counts of intermediate CD14++CD16+ monocytes (first quartile)

Outcome

First occurrence of cardiovascular death, acute myocardial infarction, or nonhemorrhagic strokecomposite

Main Result

Hazard Ratio: 3.019 (95% CI 1.315–6.928)

p-value: p=0.009

Cite This Study

Rogacev et al. (2012) conducted a cohort in Cardiovascular risk (n=951). CD14++CD16+ monocytes (fourth quartile) vs. CD14++CD16+ monocytes (first quartile) was evaluated on First occurrence of cardiovascular death, acute myocardial infarction, or nonhemorrhagic stroke (HR 3.019, 95% CI 1.315 to 6.928, p=0.009). High levels of CD14++CD16+ monocytes independently predicted cardiovascular events compared to the lowest quartile (HR 3.019; 95% CI 1.315-6.928; p=0.009).

synapsesocial.com/papers/6ab8deb6efa207e8ad26878b https://doi.org/10.1016/j.jacc.2012.07.019

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CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider