Summary: Communication between the diverse assortment of cells that constitute the tumor microenvironment plays an important role in tumor development. Using a p53-null mouse model, Zhang and colleagues describe a novel feedback loop involving breast cancer stem cells and their progeny mediated by WNT2, CXCL12, and IL6. Cancer Discov; 5(5); 469–71.
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Brooks et al. (2015) studied this question.
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