Cohort Profile Update: The Korean Genome and Epidemiology Study (KoGES)

The original cohort Key Features • The Korean Genome and Epidemiology Study (KoGES) has undergone a strategic transformation towards ageing researchwith its 245 000 participants, now in their sixties and seventies, providing an invaluable long-term resource for studying healthy ageing and longevity.• Since 2017, the cohort has expanded beyond genomics to integrate multi-omics, brain magnetic resonance imaging (MRI), gut microbiome analyses, and geocoded air-pollution data, offering a comprehensive systems biology platform.• More than 20 years of prospective follow-up and robust linkage to national health databases ensure near-complete disease ascertainment and minimal loss to follow-up.• KoGES data and biosamples have been utilized for >2000 publications and these resources are accessible to researchers through the sharing and access platforms of the National Biobank of Korea as well as the Clinical and Omics Data Archive.