Key result
First-degree T2DM family history links to substantial MetS-IR agreement with HOMA-IR at kappa ~0.65.
Why the study?
There is a significant need for rapid and cost-effective methods to assess insulin resistance, especially in non-diabetic adults with a first-degree family history of T2DM.
Does MetS-IR show good agreement with HOMA-IR for detecting insulin resistance in non-diabetic adults with a family history of T2DM?
Cross-Sectional (n=102)
Does MetS-IR show good agreement with HOMA-IR for detecting insulin resistance in non-diabetic adults with a family history of T2DM?
Answers are grounded in this paper and cite their sources.
While MetS-IR shows substantial agreement with HOMA-IR in non-diabetic adults with a first-degree family history of T2DM, it cannot yet replace HOMA-IR for detecting insulin resistance.
Background and Objective: Insulin resistance is a primary factor in the pathophysiology of Type 2 Diabetes Mellitus (T2DM). Consequently, there is a significant need in clinical practice for rapid and cost-effective methods to assess this condition. The Metabolic Score for Insulin Resistance (MetS-IR) has been developed as an alternative to the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). Given that individuals with a first-degree family history of T2DM are at a higher risk of developing insulin resistance, this study aimed to analyze the agreement between MetS-IR and HOMA-IR in non-diabetic adults with both a general and a first-degree family history of T2DM. Materials and Methods: This is an observational analytic study using a cross-sectional design, initially including 102 non-diabetic adult subjects. The analysis was focused on a sub-population of 51 subjects who had T2DM family history. Fasting glucose, fasting insulin, triglycerides (TG) and HDL-C levels were measured to calculate both MetS-IR and HOMA-IR values. A MetS-IR cut-off value of 32.83, derived from the analysis of the total population (n = 102), was used for categorization. The agreement between MetS-IR and HOMA-IR was assessed using the Kappa test. Results: The data analysis focused on 51 subjects with a family history of T2DM. Of this group, 36 subjects (70.59%) had a first-degree family history of type 2 diabetes mellitus (T2DM). The agreement test for the 51 subjects with a family history of DM yielded a Kappa value of 0.490 (p = 0.001), indicating moderate agreement. Further analysis of the sub-population with a first-degree family history (n = 36) revealed an increased Kappa value of 0.649 (p = 0.001), reflecting substantial agreement. Conclusion: A higher agreement between MetS-IR and HOMA-IR was observed in the analysis of the sub-population with a first-degree family history of T2DM. Nevertheless, based on this study's findings, the MetS-IR index cannot yet replace HOMA-IR for the detection of insulin resistance.
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Efrida et al. (2025) conducted a cross-sectional in Insulin resistance in non-diabetic adults (n=102). First-degree family history of T2DM vs. General family history of T2DM was evaluated on Agreement between MetS-IR and HOMA-IR assessed using the Kappa test (Kappa 0.649, p=0.001). A first-degree family history of T2DM in non-diabetic adults yielded substantial agreement between MetS-IR and HOMA-IR (Kappa 0.649, p=0.001), higher than in those with a general family history.
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