Isatin and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Isatin and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. In the past few decades, Isatin and its derivatives have received much attention due to their chemotherapeutic values. This review covers updated information on the most active isatin derivatives that have been reported to show considerable pharmacological actions such as antimicrobial, anticancer, antiviral, anticonvulsant, anti-inflammatory and analgesic. From these results, ideas for future molecular modifications leading to compounds with greater favorable pharmacological properties may be derived.
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Bhrigu et al. (2010) studied this question.
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