Key result
Rate pressure product fails to distinguish patients with coronary heart disease from normal controls.
Why the study?
The validity of the rate pressure product (HR x BP) as an index of myocardial oxygen consumption and its distinction between patients with CHD and normal individuals was evaluated.
Does the rate pressure product (HR x BP) distinguish between patients with and without coronary heart disease?
Cross-Sectional (n=37)
Does the rate pressure product (HR x BP) distinguish between patients with and without coronary heart disease?
The rate pressure product (HR x BP) does not reliably distinguish between patients with and without coronary heart disease, suggesting that excessive myocardial oxygen demand is not the sole pathogenic mechanism of ischemia.
Rate pressure product may not distinguish coronary disease; leaves open non-demand ischemic mechanisms for prospective validation.
The product of heart rate and blood pressure, (HR x BP), index of the myocardial oxygen consumption, was evaluated on 37 individuals with ages of between 32 and 65 years; 24 had ischemic heart disease with a disease of 1, 2 or 3 vessels, and 13 had non-significant lesions of 1 vessel (less than 75%) or no coronary heart disease (CHD). From the HR x BP correlation with the study of the angiograms of the coronary arteries, we verified that there was no distinction between patients. with CHD with or without an ejection fraction less than 50% or, with or without disturbances of myocardial contractility, and normal individuals. Thus, we believe that in patients with CHD, an excessive increase in the oxygen requirements of the myocardium is not the sole pathogenic mechanism of ischemia.
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Monteiro et al. (1982) conducted a cross-sectional in Ischemic heart disease (n=37). Rate pressure product (HR x BP) vs. Normal individuals / patients without significant CHD was evaluated on Correlation of HR x BP with coronary artery angiogram findings. The rate pressure product (HR x BP) showed no distinction between the 24 patients with coronary heart disease and 13 normal individuals regarding angiographic findings.
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