Key result
Simple ordinal CAC score on thorax CT predicts MACE with an AUC of ~0.91.
Why the study?
Does a simple Ordinal Coronary Artery Calcification score on thorax CT predict 30-day MACE in adult patients presenting to the emergency department with chest pain?
Cross-Sectional (n=49)
Blinded to clinical information
No
Does a simple Ordinal Coronary Artery Calcification score on thorax CT predict 30-day MACE in adult patients presenting to the emergency department with chest pain?
A simple Ordinal Coronary Artery Calcification score assessed on routine non-contrast thorax CT by emergency physicians demonstrates high sensitivity and moderate specificity for predicting 30-day MACE in patients presenting with acute chest pain.
Answers are grounded in this paper and cite their sources.
May support ED chest pain risk stratification; leaves open prospective validation before practice change.
Aim: Chest pain is one of the most common reasons for visiting the emergency department (ED). This study aimed to determine the diagnostic performance of the simple Ordinal Score in predicting 30-day major adverse cardiac events (MACE) in adult patients presenting to the ED with chest pain.Material and Methods: This single-center, cross-sectional study was conducted at the ED of a tertiary teaching and research hospital. All patients who presented with chest pain who did not meet the exclusion criteria were included. The simple Ordinal score was independently assessed on thorax computed tomography (CT) scans. The effectiveness of the simple Ordinal score in predicting MACE was evaluated using a receiver operating characteristic (ROC) curve analysis and diagnostic test characteristics.Results: Forty-nine patients were included in the study. MACE occurred in 10 patients but not in the remaining 39 patients. The area under the curve (AUC) for the simple Ordinal score assessed by the emergency medicine specialist (EMS) was 0.913, and the cut-off value was (≥ 4), with a sensitivity of 90.0% (95% CI, 55.5% - 99.8%) and a specificity of 74.4% (95% CI, 57.9% - 87.0%). The AUC for the simple Ordinal score by the radiologist was 0.921, and the cut-off value was (≥ 4), with a sensitivity of 90.0% (95% CI, 55.5% - 99.8%) and a specificity of 84.6% (95% CI, 69.5% - 94.1%).Conclusion: The simple Ordinal score, assessed by an EMS on thorax CT, has high sensitivity and moderate specificity for detecting MACE in patients with chest pain.
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Yazıcı et al. (2026) conducted a cross-sectional in Acute chest pain (n=49). Simple Ordinal Coronary Artery Calcification Score vs. HEART score was evaluated on 30-day major adverse cardiac events (MACE) (AUC 0.913, 95% CI 0.782-0.995). The simple Ordinal coronary artery calcification score assessed on thorax CT predicted 30-day major adverse cardiac events with an AUC of 0.913, 90.0% sensitivity, and 74.4% specificity.
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