Adapalene‐Associated Cutaneous Adverse Events: A Disproportionality Analysis of the FAERS Database

To the Editor, Adapalene is a third-generation topical retinoid which is highly effective, generally well-tolerated first-line topical treatment for acne [1,2].Its expected local effects, including dryness, erythema, burning, scaling, and irritation, are familiar to dermatologists.However, spontaneous-reporting data may capture a wider spectrum of cutaneous terms, including events that overlap with the treated disease or are not explicitly represented in product labeling.