Key result
P2 receptor blockade with pyridoxine augmented resting cutaneous vasodilation in the heat by a mean difference of 18 %CVCmax compared to control, but had no influence during and following exercise.
Why the study?
Does P2 receptor blockade affect cutaneous vasodilation in young men at rest and during exercise in the heat?
RCT (n=12)
Counter-balanced
No
Does P2 receptor blockade affect cutaneous vasodilation in young men at rest and during exercise in the heat?
P2 receptors appear to play a functional role in the regulation of cutaneous vascular tone during ambient heat exposure at rest.
Answers are grounded in this paper and cite their sources.
Does not support clinical use in heat stress; leaves open P2 receptor roles during exercise hyperemia.
We assessed the role of purinergic P2 receptors in the regulation of cutaneous vasodilation in young adults at rest and during intermittent moderate-intensity exercise in the heat (35 °C). P2 receptor blockade augmented resting cutaneous vasodilation but had no influence during and following exercise. This increase was partly diminished by nitric oxide synthase inhibition. These results suggest a functional role of P2 receptors in the regulation of cutaneous vascular tone during ambient heat exposure at rest.
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Fujii et al. (2017) conducted an RCT in Healthy (n=12). Pyridoxine (P2 receptor blockade) vs. Lactated Ringer's solution was evaluated on Cutaneous vascular conductance (%CVCmax) during baseline resting (Mean difference of 18 %CVCmax, 95% CI 10-26, p=≤0.05). P2 receptor blockade with pyridoxine augmented resting cutaneous vasodilation in the heat by a mean difference of 18 %CVCmax compared to control, but had no influence during and following exercise.
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