Key result
Patient activation, SBP, physical activity, education, smoking, and abdominal diameter explain ~66% of treatment adherence variance.
Why the study?
A large number of hypertensive patients do not adhere to their treatment regimen, and predictors of treatment adherence need to be identified.
Cross-Sectional (n=500)
Yes
Patient activation, systolic blood pressure, physical activity, education, smoking history, and abdominal diameter are significant predictors of treatment adherence in hypertensive patients.
These predictors may inform adherence screening in primary care hypertension; leaves open need for longitudinal validation and intervention trials.
Treatment adherence is a pivotal component of hypertension management. A large number of hypertensive patients do not adhere to their treatment regimen. This study aimed to identify the predictors of treatment adherence among hypertensive patients. This multicenter cross-sectional study was conducted between November 2025 and January 2026 in northwestern Iran. Five hundred eligible hypertensive patients were selected using a clustered random sampling method. Data were collected using a demographic questionnaire, the Patient Activation Measure (PAM), and the Treatment Adherence Questionnaire for Patients with Hypertension (TAQPH). Data were analyzed using descriptive and inferential statistics. SPSS ver.21 software was used for data analysis. The Mean ± SD of treatment adherence was 88.44 ± 7.01. It was found that treatment adherence had a direct correlation with patient activation. Also, a negative correlation was detected between treatment adherence with blood pressure and duration of disease. The multiple linear regression model revealed that patient activation, SBP, physical activity, education, history of smoking, and abdominal diameter were the main predictors of treatment adherence (adjusted R square = 0.66). Hypertensive patients’ treatment adherence is good but not optimal. Based on the results, improvement of patient activation should be prioritized. Also, weight loss, daily activity, and quitting smoking are recommended.
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Shakib et al. (2026) conducted a cross-sectional in Hypertension (n=500). Patient activation and clinical/demographic factors was evaluated on Treatment adherence score (TAQPH) (Adjusted R square = 0.66). Patient activation, systolic blood pressure, physical activity, education, history of smoking, and abdominal diameter were identified as the main predictors of treatment adherence, explaining 66% of its variance.
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