Key result
Perioperative optimization of volume replacement decreases morbidity and mortality at the initial stage of aggression, while excess volume replacement at a later period can be harmful.
Why the study?
Does perioperative optimization of oxygen delivery and volume replacement reduce morbidity and mortality in patients during the operative period or initial phase of septic shock?
Does perioperative optimization of oxygen delivery and volume replacement reduce morbidity and mortality in patients during the operative period or initial phase of septic shock?
Early perioperative optimization of volume replacement decreases morbidity and mortality, whereas late excess volume can be harmful.
Answers are grounded in this paper and cite their sources.
May support stage-specific perioperative fluid strategies; leaves open optimal thresholds pending randomized trials.
SUMMARY The concept of perioperative hemodynamic optimization was developed by Shoemaker in the early 1980s. The controversy concerning optimization of oxygen delivery persists as recent studies show that the timing of this optimization appears to be an essential factor. At the initial stage of aggression (operative period, initial phase of septic shock), optimization of volume replacement decreases morbidity and mortality, while at a later period excess volume replacement can be harmful for the patient. The aim of this article is to review the physiological methods and indications for optimization of oxygen delivery.
No takes yet. Share an insight, caveat, or question.
Conte et al. (2010) conducted a review in Perioperative hemodynamic optimization. Perioperative optimization of oxygen delivery was evaluated. Perioperative optimization of volume replacement decreases morbidity and mortality at the initial stage of aggression, while excess volume replacement at a later period can be harmful.
Synapse has enriched 10 related papers. Consider them for comparative context: