Key result
ANGPTL4 exerts dual pro- and anti-inflammatory effects across inflammatory disease states.
Why the study?
ANGPTL4 has pleiotropic functions with both anti- and pro-inflammatory properties, but its dual role in inflammation remains unclear.
This review highlights the complex, dual role of ANGPTL4 in inflammation, suggesting its potential as a target for drug discovery.
Dual ANGPTL4 roles in inflammation leave its net therapeutic effect unresolved; hypothesis-generating for targeted validation.
Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like protein family and mediates the inhibition of lipoprotein lipase activity. Emerging evidence suggests that ANGPTL4 has pleiotropic functions with anti- and pro-inflammatory properties. Here, we have reviewed the research progress on ANGPTL4 and systematically discussed the dual role of ANGPTL4 in inflammation and inflammatory diseases. Understanding the potential mechanisms of ANGPTL4 in inflammation will aid in drug discovery and treatment development.
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Zuo et al. (2023) conducted a review in Inflammation and inflammatory diseases. ANGPTL4 was evaluated. ANGPTL4 exhibits pleiotropic functions with both anti- and pro-inflammatory properties in the context of inflammation and inflammatory diseases.
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