Key result
Posterior decompression and fixation improves paralysis after cervical spinal cord injury in Coffin-Lowry syndrome.
Why the study?
Coffin-Lowry syndrome is associated with vertebral diseases and a high risk of falls leading to traumatic cervical spinal cord injury, but reports on management are limited.
Case Report (n=1)
Case report detailing posterior decompression and fixation for cervical spinal cord injury in a patient with Coffin-Lowry syndrome.
May support posterior fixation for cervical injury in Coffin-Lowry syndrome; leaves open generalizability beyond this single case.
Background : Coffin-Lowry syndrome (CLS) is a rare, X-linked disease characterized by mental retardation, facial dysmorphism, musculoskeletal abnormalities, cardiac abnormalities, and stimulus-induced drop episodes. Various vertebral diseases, such as scoliosis, develop as a consequence of this disease, and there are reports on the calcification of the cervical ligamentum flavum. The risk of falls is reported to be high as a result of developmental disability and stimulus-induced drop episodes, often leading to traumatic cervical spinal cord injury (SCI). We present the case of a patient with CLS who had calcification of the cervical ligamentum flavum and atlantoaxial subluxation. This patient also experienced cervical SCI due to a fall.
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Ikeuchi et al. (2021) conducted a case report in Cervical spinal cord injury with atlantoaxial subluxation and calcification of cervical ligamentum flavum in Coffin-Lowry Syndrome (n=1). C1-4 posterior fixation and C2-4 laminectomy was evaluated on Neurological improvement. C1-4 posterior fixation and C2-4 laminectomy successfully improved paralysis without new neurological abnormalities in a 12-year-old male with Coffin-Lowry syndrome and cervical spinal cord injury.
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