Key result
Complex ventricular arrhythmias during hemodialysis are linked to ~37 mmHg lower minimum blood pressure.
Why the study?
Characteristics of routine examinations among patients showing complex ventricular arrhythmias during hemodialysis were unclear.
Is the presence of complex ventricular arrhythmias during hemodialysis associated with unstable blood pressure in chronic hemodialysis patients?
Observational (n=18)
Is the presence of complex ventricular arrhythmias during hemodialysis associated with unstable blood pressure in chronic hemodialysis patients?
Complex ventricular arrhythmias during hemodialysis are associated with significant blood pressure instability, which may reflect reduced arterial compliance and low coronary perfusion.
May flag CVA risk via routine labs in hemodialysis; hypothesis-generating and requires larger prospective validation.
Purpose: To clarify characteristics of the routine examinations among the patients who show complex ventricular arrhythmias (CVA) during hemodialysis. Methods: Holter monitoring was performed in 18 chronic hemodialysis patients (12 male/ 6 female, mean 60.6 years old). Between the groups of patients with or without CVA during hemodialysis, various parameters including the patient's background and clinical examinations routinely investigated. Results: The background of the patients and clinical investigation revealed no significant difference between CVA+ and CVApatients. Both minimum systolic and diastolic blood pressure revealed difference between CVA+ and CVApatients (98.7±10.3 vs. 135.5±5.4mmHg; P<0.01). Moreover, mean (maximum systolic blood pressure-minimum systolic blood pressure) of CVA+ patients was significantly higher than that of CVApatients (42±8 vs 18±6 mmHg; P<0.05). Conclusion: The patients with CVA during hemodialysis have instability of blood pressure, which suggests their reduced arterial compliance, ventricular hypertrophy and low coronary perfusion. This work was supported by research grants from Ministry of Education, Culture, Sports, Science and Technology, Japan, and from the University of Tsukuba.
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A 2005 study conducted an observational in Chronic hemodialysis (n=18). Complex ventricular arrhythmias (CVA) vs. No complex ventricular arrhythmias was evaluated on Minimum blood pressure (p=<0.01). Complex ventricular arrhythmias during hemodialysis were associated with significantly lower minimum blood pressure compared to patients without arrhythmias (98.7 vs 135.5 mmHg; P<0.01).
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