Key result
Human albumin infusion reduced platelet activation by reducing oxidative stress in two patients with congenital analbuminemia.
Why the study?
Does human albumin infusion reduce platelet activation and oxidative stress in patients with congenital analbuminemia?
Case Report (n=2)
Does human albumin infusion reduce platelet activation and oxidative stress in patients with congenital analbuminemia?
Albumin infusion acutely reduces platelet activation and oxidative stress in patients with the rare disorder congenital analbuminemia.
Answers are grounded in this paper and cite their sources.
May support albumin in congenital analbuminemia; hypothesis-generating and should not change practice.
BACKGROUND AND AIMS: Congenital analbuminemia is a rare autosomal recessive inherited disorder characterized by strongly decreased concentration, or complete absence, of serum albumin (SA). Several lines of evidence indicate that SA has anti-thrombotic effect. In vivo platelet function and the role of oxidative stress (OS) in platelet aggregation promotion have never been studied in analbuminaemic patients. PATIENTS AND METHODS: We report two cases of congenital analbuminemia in a 38-year-old male and in a 67-year-old woman. We analyzed platelet activation (PA) and OS at baseline and 2 h after 40 g human albumin infusion. PA was evaluated as platelet aggregation, sCD40L and surface αIIbβ3 integrin and P-selectin expression. OS was evaluated measuring serum sNOX2dp, and 8-iso-PGF2α. FINDINGS: Analbuminemic patients displayed higher platelet aggregation, markers of PA and of OS. Albumin infusion reduced platelet activation by reducing oxidative stress.
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Baratta et al. (2021) conducted a case report in Congenital analbuminemia (n=2). Human albumin infusion vs. Baseline was evaluated on Platelet activation and oxidative stress. Human albumin infusion reduced platelet activation by reducing oxidative stress in two patients with congenital analbuminemia.
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