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June 1, 2017Circulation Arrhythmia and ElectrophysiologyOpen Access

Electrocardiographic Preexcitation and Risk of Cardiovascular Morbidity and Mortality

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Key result

Electrocardiographic preexcitation was associated with higher hazards of atrial fibrillation (HR 3.12; 95% CI 2.07-4.70) and heart failure (HR 2.11; 95% CI 1.27-3.50) in a primary care population.

Why the study?

Does electrocardiographic preexcitation increase the risk of cardiovascular morbidity and mortality in a primary care population?

Population

328,638 primary care patients from Danish nationwide registries, including 310 individuals with…

Comparison

Electrocardiographic preexcitation vs Remainder of the primary care population without…

Design

Cohort

Follow-up

median 7.4 years

Authors

MSMorten Wagner SkovPRPeter Vibe RasmussenJGJonas Ghouse

Discussion

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Overview

May prompt closer AF/HF monitoring in primary care preexcitation; extends observational data but leaves causal effects open to trials.

Study Design

Type

Cohort (n=328,638)

Multicenter

Yes

Structured PICO

Does electrocardiographic preexcitation increase the risk of cardiovascular morbidity and mortality in a primary care population?

P
Population
328,638 primary care patients, including 310 with electrocardiographic preexcitation (age 8-85 years), followed for a median of 7.4 years.
E
Exposure
Electrocardiographic preexcitation
C
Comparator
Remainder of the primary care population without preexcitation
O
Outcome
Cardiovascular morbidity (atrial fibrillation, heart failure) and mortalityhard clinical

Main Result

Hazard Ratio: 3.12 (95% CI 2.07–4.7)

Electrocardiographic preexcitation in a primary care population is associated with significantly higher risks of atrial fibrillation and heart failure, and increased mortality in patients aged 65 or older.

Cite This Study

Skov et al. (2017) conducted a cohort in Electrocardiographic preexcitation (n=328,638). Electrocardiographic preexcitation vs. Remainder of the population was evaluated on Atrial fibrillation (HR 3.12, 95% CI 2.07-4.70). Electrocardiographic preexcitation was associated with higher hazards of atrial fibrillation (HR 3.12; 95% CI 2.07-4.70) and heart failure (HR 2.11; 95% CI 1.27-3.50) in a primary care population.

synapsesocial.com/papers/6ab9d9a15ea4490331b76b03https://doi.org/10.1161/circep.116.004778
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