BE-24566B, a New Antibiotic Produced by Streptomyces violaceusniger.

In the course of our screening program for new antibacterial compounds, a strain A24566 isolated from a lichen collected at Jyogasaki, Shizuoka prefecture, Japan, was found to produce a potent antibiotic.This compound, BE-24566B (1), was isolated from the mycelial cake of cultural broth, and was shown to have the unique structure in Fig. 1.BE-24566B possesses potent antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).This paper describes the strain, production, isolation, physico-chemical properties and structure elucidation of this new antibiotic.