Antibacterial and toxicity studies of the ethanol extract of Musa paradisiaca leaf

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The ethanol extract of the leaf of Musa paradisiaca and its aqueous fraction were investigated for antibacterial potentials against Gram-positive and Gram-negative organisms of clinical importance. Phytochemical screenings showed the presence of secondary metabolites namely tannin, flavonoids, alkaloids among others. When the extracts were subjected to susceptibility test, results showed that while both the ethanol extract and its aqueous fraction showed activity against the test organisms, the aqueous fraction showed better antibacterial activity. The minimum inhibitory concentration of the aqueous fraction ranged from 3.125 to 25 mg/ml. Acute toxicity test of the aqueous fraction using Swiss Albino mice gave an LD50 of 489.9 mg/kg body weight which indicates a relative toxicity of the extract. The time–kill studies demonstrated a reduction in the viable cell count for the extract.