HPLC determination of tocopherol, retinol, dehydroretinol and retinyl palmitate in tissues of lake char (Salvelinus namaycush) exposed to coplanar 3,3′,4,4′,5-pentachlorobiphenyl

Tocopherol, retinol, dehydroretinol, and retinyl palmitate were measured by reversed-phase HPLC in liver, kidney, and plasma of lake char exposed to orally administered coplanar 3,3′,4,4′,5-pentachlorobiphenyl (PCB). Tocopherol concentrations were unaffected after eight weeks. Liver retinol, dehydroretinol, and retinyl palmitate concentrations were lower, whereas kidney retinyl palmitate was elevated in PCB-exposed groups. Tissue retinoid concentrations provide sensitive indicators of coplanar PCB exposure in fish.