Key result
Targeted microbubble contrast ultrasound enables molecular imaging of cardiovascular inflammation.
Why the study?
Imaging key aspects of the immune response in cardiovascular disease could improve diagnosis, prognosis, and therapy customization, but targeted ultrasound molecular imaging strategies require review.
How can contrast ultrasound molecular imaging be used to assess inflammation in cardiovascular disease?
How can contrast ultrasound molecular imaging be used to assess inflammation in cardiovascular disease?
Contrast ultrasound molecular imaging using targeted microbubbles offers a promising approach to assess inflammation in various cardiovascular diseases, potentially improving diagnosis and risk stratification.
May enable noninvasive detection of vascular inflammation in CVD; leaves open clinical adoption pending prospective validation.
The cellular immune response plays an important role in almost every major form of cardiovascular disease. The ability to image the key aspects of the immune response in the clinical setting could be used to improve diagnostic information, to provide important prognostic or risk information, and to customize therapy according to disease phenotype. Accordingly, targeted imaging probes for assessing inflammation have been developed for essentially all forms of medical imaging. Molecular imaging of inflammation with contrast ultrasound relies on the detection of targeted microbubble or other gas-filled particle contrast agents. These agents are confined to the vascular space and, hence, have been targeted to either activated leucocytes or endothelial cell adhesion molecules that are upregulated in inflammation and mediate leucocyte recruitment and adhesion. This review focuses on the inflammation-targeting strategies for ultrasound contrast agents and how they have been matched to cardiovascular disease states such as myocardial ischaemia, infarction, atherosclerosis, transplant rejection, and arteriogenesis.
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Jonathan R. Lindner (2009) conducted a review in Cardiovascular disease. Contrast ultrasound molecular imaging was evaluated. Contrast ultrasound molecular imaging using targeted microbubbles can assess inflammation in cardiovascular diseases by detecting activated leucocytes or endothelial cell adhesion molecules.
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