Urinary tract infection in outpatients in Germany: a cross-sectional study of diagnostics and susceptibility testing in medical laboratories

This is the authors' abstract. We don't add key points for this paper.

BACKGROUND: Urinary tract infections (UTIs) are common, representing a frequent cause of antibiotic prescription in primary care worldwide. Selection of antibiotics for antimicrobial susceptibility testing and the reporting of test results by laboratories can directly impact antibiotic prescribing and guideline adherence. AIM: To assess the current practice of susceptibility testing by laboratories for outpatient UTIs in Germany. DESIGN & SETTING: A cross-sectional study was conducted including all laboratories identified by searching for specialists in laboratory medicine and microbiology on the websites of the 17 German associations of statutory health insurance physicians. METHOD: Between January and April 2024, a survey using a standardised questionnaire was conducted across identified laboratories. The most commonly tested antibiotics were ciprofloxacin (98.1%), co-trimoxazole (97.2%), cefuroxime, and nitrofurantoin (both 91.5%). On average, laboratories tested 3.8 of the five antibiotics recommended in the German guidelines on uncomplicated UTI, with 26.4% testing for all five. Laboratories received clinical information on previous treatments and comorbidities in an estimated one-fifth (on average 21.3% and 21.5%, respectively) of the urine samples, and information on the type of the urine sample in an estimated three-fifths (63.7%) of samples. CONCLUSION: Laboratories should test and report as many first-line antibiotics as possible. Further, a more detailed and standardised transfer of clinical information to laboratories could enhance the quality of antibiotic prescribing.