The purpose of this study was to determine whether priming-dose schedules of Cytoxan (Cyt) could result in increased antileukemic effectiveness in L1210 leukemic mice. In three experiments, each initial dose of Cyt was followed by various schedules of Cyt. When the interval between doses was short (2 days), the optimal treatment was found to consist of a high priming dose followed by markedly reduced regular doses. At longer intervals (5 and 7 days), the optimal modality was a constant-dose schedule. On constant-dose schedules, a longer interval between treatments was advantageous. When loading-dose schedules were included, the longest surviving group was observed when a shorter interval was employed.
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Straus et al. (1974) studied this question.
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